In a new publication in Nature Communications, a team of PROXIDRUGS researchers at Goethe University Frankfurt, working within the InnoDATA project, reports the first comprehensive, data-driven classification of all human E3 ubiquitin ligases. The study presents a systematic map of the human “E3 ligome” and provides new insights into the functional relationships among E3 ligases.   Using AI-supported computational analyses combined with experimental validation, the researchers classified E3...

On December 2 and 3, the PROXIDRUGS annual meeting 2025 brought the cluster community together for the fifth time for two days of inspiring scientific exchange and productive discussions. Partners from across the PROXIDRUGS consortium met in person alongside members of the advisory board and representatives from Projektträger Jülich, creating a dynamic and collaborative atmosphere. Bringing the entire cluster community together once again highlighted the exceptional value of direct...

A new study published in the Journal of Medicinal Chemistry sheds light on how conformational changes in macrocycles are tightly coupled and propagated in a domino-like cascade, ultimately governing their overall behavior. This multi-institutional effort brought together PROXIDRUGS members from TU Darmstadt, Fraunhofer ITMP, and AbbVie, alongside collaborators from ETH Zurich and the Max Planck Institute in Munich, combining complementary experimental and computational expertise. The...