PROXIDRUGS–MTI Workshop on Induced Proximity Therapeutics

The PROXIDRUGS–MTI Workshop on Induced Proximity Therapeutics brought together researchers from Germany and the United States for several days of scientific exchange, discussion, and collaboration on one of the most dynamic frontiers in biomedical research: therapeutic modalities acting by induced proximity.

Organized by Ivan Đikić and Michael Rapé as part of the BMFTR-funded ProxiUS project, the workshop marked the launch of a transatlantic exchange between PROXIDRUGS and the Molecular Therapeutics Initiative at the University of California, Berkeley.

The workshop showcased remarkable scientific advances spanning molecular glues, targeted degradation via proteasomal and autophagic-lysosomal pathways, and emerging modalities acting through proximity-induced mechanisms. Discussions also addressed the broader innovation pathway of proximity-based therapeutics, from fundamental biology and proximity chemistry to medicinal chemistry, drug discovery, clinical perspectives, and translational efforts in areas including cancer, neurodegeneration, cardiovascular disease, and drug delivery.

A recurring theme throughout the meeting was the close interplay between academic discovery and biotechnology. While academia is uniquely positioned to uncover new biological principles, decipher mechanisms, and explore high-risk ideas, the focused development expertise and resources of biotechnology and industry are essential for translating these insights into therapeutic innovation. Perspectives from Merck and Enamine Germany, established industry partners within the PROXIDRUGS network, further enriched the exchange and highlighted that innovation is rarely a linear handover, but rather an iterative process in which discovery and development continuously inform, challenge, and accelerate one another.

The small and highly interactive format fostered lively discussions well beyond the lecture hall. The workshop sparked numerous bilateral discussions, new project ideas, and opportunities for future collaboration, underscoring the value of transatlantic partnerships in advancing induced proximity therapeutics from fundamental discovery toward future therapies.

PROXIDRUGS extends its sincere thanks to Ivan Đikić, Michael Rapé, all speakers, organizers, and participants for creating such an open, stimulating, and collaborative environment. We look forward to seeing the ideas and collaborations initiated during the workshop continue to grow.

The workshop was organized within the BMFTR-funded ProxiUS project, with support from Projektträger Jülich and DLR Projektträger.

Photo credit: PROXIDRUGS Cluster