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Book chapter: AI-aided drug development for protein degraders: Design, lead identification, and optimization
A new chapter in the book series Annual Reports in Medicinal Chemistry (Academic Press, 2025) was published by scientist from PROXIDRUGS partner Fraunhofer ITMP. It offers a comprehensive overview of AI-driven methods in the design and application of proximity-inducing therapeutics (proxidrugs). After introducing targeted protein degradation, the chapter examines the key challenges in proxidrug design and the role of computational methods. It also provides a broader perspect
Oct 30, 2025
Rewiring the SUMO–Ubiquitin System for Next-Generation Therapies
In their recent review (published in Trends in Pharmacological Sciences) Gina Gotthardt, PROXIDRUGS researcher Jan Keiten-Schmitz, and PROXIDRUG PI Stefan Müller discuss how SUMO-signaling and SUMO-targeted ubiquitin ligases (StUbLs) can be exploited to inactivate disease-associated proteins. The review explores the new therapeutic possibilities that this opens within the field of drug discovery utilizing the ubiquitin-proteasome system. Established cancer treatments are harn
Oct 20, 2025
European alliance to advance proximity-induced drug modalities
Scientists from leading European research institutions, Goethe University Frankfurt, IRB Barcelona, AITHYRA in Vienna, the University of...
Aug 20, 2025
Publication in GIT Labor-Fachzeitschrift: Accelerated Discovery of Proximity-Inducing Compounds
A recent article by Thorsten Mosler (Goethe University) in collaboration with researchers from Revvity Cellular Technologies (Sara...
Aug 11, 2025
White paper – From PROTACs to DACs: How targeted protein degraders are breaking rules and boundaries in drug design
Protein degraders, such as proteolysis-targeting chimeras (PROTACs) and other chimeric targeted protein degraders, represent a highly...
Jun 27, 2025
PROXIDRUGS and Futury initiate strategic cooperation to promote life science start-ups
The Cluster4Future PROXIDRUGS and the innovation platform Futury GmbH have formed a strategic partnership with the aim of setting new...
May 26, 2025
Pharmaceutical exchange meeting at the University Hospital Frankfurt am Main
On 8th of May 2025, the House of Pharma & Healthcare organised an exchange on the potential of pharmaceutical research at the University...
May 13, 2025
Broad target screening reveals abundance of FKBP12-based molecular glues in focused libraries
A new publication in the Journal of Medicinal Chemistry the PROXIDRUGS project leader Felix Hausch and his team from TU Darmstadt,...
May 5, 2025
Drug Discovery am Main - public event to mark the start of the second phase of PROXIDRUGS
On 22 April, the PROXIDRUGS Cluster4Future together with its partner House of Pharma & Healthcare hosted a public event on the Niederrad...
Apr 30, 2025
Cellular ‘Roadside Assistance’ may prevent harmful TDP-43 aggregates
In their publication in Nature Chemical Biology PROXIDRUGS researchers and collaborating universities have discovered a way to prevent...
Apr 17, 2025
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