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Third ERC Advanced Grant to Ivan Đikić

PROXIDRUGS speaker Ivan Đikić has been awarded with an Advanced Grant of the European Research Council (ERC). This is the third time he receives the prestigious grant that comes along with research funding in the amount of € 2.5 million for the next five years. With his grant, Ivan Đikić intends to unravel molecular mechanisms of endoplasmic reticulum (ER) remodelling via ER-phagy pathways. The endoplasmic reticulum (ER) is the largest intracellular membrane system and covers important functions in numerous processes. It is essential for cellular homeostasis and wellbeing. To fulfill its diverse functions, the ER is constantly adapting its shape, and Ivan Đikić is amongst the pioneers in shedding light on the regulation of these dynamic changes. He postulated that ER-phagy, a selective autophagy route targeting ER, is a major driver of ER remodeling and found first molecular cues on how this process is regulated.





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